منابع مشابه
Polarity establishment in yeast.
The unicellular yeast Saccharomyces cerevisiae is a model system for the establishment of cell polarity. Yeast cells proliferate by budding, which involves specialization of a small patch of the mother cell cortex and polarization of many cell constituents towards that patch, promoting growth of the bud. Genetic approaches have uncovered a large number of genes involved in these processes, yiel...
متن کاملEstablishment of cell polarity in yeast.
The establishment of cell polarity is a central feature of morphogenesis in many types of cells (Schnepf 1986; Horvitz and Herskowitz 1992; Rodriguez-Boulan and Nelson 1993; Shapiro 1993; Priess 1994). Polarity establishment involves selection of an axis of polarization followed by the asymmetric organization of cytoskeletal elements, membranous organdíes, components of the plasma membrane, and...
متن کاملNegative Feedback and Competition in the Yeast Polarity Establishment Circuit
Negative Feedback and Competition in the Yeast Polarity Establishment Circuit by Chi-Fang Wu University Program in Genetics and Genomics Duke University Date:_______________________ Approved: ___________________________ Daniel Lew, Supervisor ___________________________ Patrick Brennwald ___________________________ Steve Haase ___________________________ David Sherwood _________________________...
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Many cells undergo symmetry-breaking polarization toward a randomly oriented "front" in the absence of spatial cues. In budding yeast, such polarization involves a positive feedback loop that enables amplification of stochastically arising clusters of polarity factors. Previous mathematical modeling suggested that, if more than one cluster were amplified, the clusters would compete for limiting...
متن کاملSymmetry breaking and the establishment of cell polarity in budding yeast.
Cell polarity is typically oriented by external cues such as cell-cell contacts, chemoattractants, or morphogen gradients. In the absence of such cues, however, many cells can spontaneously polarize in a random direction, suggesting the existence of an internal polarity-generating mechanism whose direction can be spatially biased by external cues. Spontaneous 'symmetry-breaking' polarization is...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2004
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.00953